The show is centered on Orange (voiced by Dane Boedigheimer), who resides on a fruit cart display in a kitchen with other objects such as his best friend, Pear, an irritable Bartlett pear (also voiced by Boedigheimer). Other fruits include Passion, a sensible passion fruit and Orange's love interest played by iJustine, an arrogant grapefruit (voiced by Robert Jennings), a tiny miserable and frustrated but hot-blooded apple known as Midget Apple (though he prefers the name Little Apple), a happy-go-lucky and slightly eccentric marshmallow of ambiguous gender, and an elderly, yet sleepy, lemon named Grandpa Lemon, all of whom were not main characters until later episodes.
Most episodes consist of Orange heckling other characters until they meet a sudden and gruesome end, usually by evisceration with a chef's knife (although the implements used to cut them up range from a blender to a toy pinwheel). Usually, Orange tries to "warn" them before it happens, blurting out the weapon-in-use, such as "Knife!"
Orange has several recurring mannerisms. He often begins an episode by repeatedly yelling "Hey, (name of character)!" until the character responds. Orange also often refers to the character as something that plays on the object's name or appearance (such as calling Grapefruit "Apefruit"). If he does not like an object, he will often say "You're an apple!", even if the object is not (e.g., a tomato). Orange uses various tactics, such as telling rude and offensive jokes, burping and making childish noises with his tongue, to get attention.
Despite what other fruits and objects think, Orange often cannot control his tendency to be "annoying," and rarely intentionally tries to spite others; he usually means well for most fruits and objects. In one episode of the web series, a "life coach," Mango, suggests that Orange uses his annoying nature to try to cope with the destruction of the fruits he tries to make friends with.
Regardless of his seemingly anti-social behavior, Orange can almost always find comfort in the company of his friends and sometimes makes new ones.