Nurse Betty (2000)

Nurse Betty is a 2000 American black comedy film directed by Neil LaBute and starring Renée Zellweger as a Kansas waitress who suffers a nervous breakdown after witnessing her husband's murder, and starts obsessively pursuing her favorite soap actor (Greg Kinnear), while in a fugue state. Morgan Freeman and Chris Rock play the hitmen who killed her husband and subsequently pursue her to Los Angeles.

For her performance, Zellweger won the Golden Globe Award for Best Actress – Motion Picture Musical or Comedy.